Up- and Down-regulated Leukemia-related Protein 16 Affects ERα Expression and Prolactin Secretion by GH3 Cells / 生物医学与环境科学（英文）

Prolactinoma is an estrogen-related tumor and leukemia-related protein 16 (LRP16) is correlated with the progression of estrogen-related tumors, but the regulatory mechanism between LRP16 and prolactinoma remain unclear. This study demonstrates a variation in LRP16 with estrogen receptor α (ERα) in prolactinoma models and the up and downregulation effects of LRP16 on prolactin secretion of pituitary adenomas cells (GH3 cells). In our study, 50 male SD rats (30-day-old) were randomly divided into five groups of 10 rats each. After 120 days of treatment, the rats were sacrificed, and the expression of LRP16 and ERα were examined by Western blot and immunohistochemistry to explore the changes in ERα, LRP16, and prolactin. After siRNA transfection of the respective genes, the GH3 cells were cultured, and their secretory function as well as the expression of ERα mRNA and prolactin were analyzed by enzyme-linked immunosorbent assay and real-time-polymerase chain reaction analysis. The results show that secretion of prolactin by GH3 cells can be affected by up and downregulating LRP16 expression, which may provide a novel medical therapy in clinical trials.

Magnetic resonance imaging assessment of the lateral pterygoid muscle in Class III malocclusion subjects / 中华口腔医学杂志

<p><b>OBJECTIVE</b>To analyze the relationship between Class III malocclusion and pathological changes in temporomandibular joint (TMJ) structures using magnetic resenonce imaging (MRI).</p><p><b>METHODS</b>Twenty-four Class III malocclusion adult patients and 10 normal control cases were included in the study. The characteristics of lateral pertygoid muscle (LPM) in the sample group and the control group were assessed.</p><p><b>RESULTS</b>More pathological changes of LPM were found in Class III malocclusion adult patients (36 TMJ). The changes included hypertrophy, atrophy and contracture. And there was no relation between the pathological changes of LPM and the symptom of temporomandibular disorders (TMD).</p><p><b>CONCLUSIONS</b>The frequency of pathological changes of LPM was greater in patients with Class III malocclusion than in the control group.</p>

Relationship between condyle movement and disc position in patients with Class II division 1 malocclusion / 中华口腔医学杂志

<p><b>OBJECTIVE</b>To investigate the relationship between condyle movement and temporomandibular disorders (TMD) in patients with Class II division 1 malocclusion.</p><p><b>METHODS</b>Twenty patients (from 11 to 12 years old) with Class II division 1 malocclusion before treatment were collected. Computer aided diagnosis axiograph (CADIAX) and magnetic resonance images (MRI) were used to analyze the condyle movement between disc displacement and normal groups.</p><p><b>RESULTS</b>The sensitive values were found in open/close process in patients with disc displacement: Y [Left: (0.32 +/- 0.10) mm, Right: (-0.91 +/- 0.49) mm ], Z [Left: (4.20 +/- 0.70) mm, Right: (3.44 +/- 0.21) mm], sagittal condylar inclination (SCI) [Left: (32.48 +/- 7.70) degrees , Right: (33.47 +/- 12.60) degrees ] and horizontal condylar inclination (TCI) [Left: (-2.60 +/- 2.02) degrees , R: (-9.23 +/- 5.58) degrees ], and those items showed significant difference between two groups.</p><p><b>CONCLUSIONS</b>The side shift of condyle movement in maximum open/close process might be the inducement of disc displacement. It was revealed that the changes in condyle movement could give useful information in early stage of functional treatment.</p>

Relationships between MRI image changes of lateral pterygoid muscle, disc position and condylar mobility in Class II patients / 中华口腔医学杂志

<p><b>OBJECTIVE</b>To analyze the relationships between MRI image changes of lateral pterygoid muscle (LPM), disc position and condylar mobility.</p><p><b>METHODS</b>Twenty Class II patients were chosen and MRI images of LPM were taken. The relationships between MRI image changes of LPM, disc position and condylar mobility were analyzed.</p><p><b>RESULTS</b>The rate of MRI image changes of LPM in Class II patients was about 45%. No significant correlations were found between MRI image changes of LPM, condylar mobility and disc position.</p><p><b>CONCLUSIONS</b>MRI image changes of LPM in Class II patients was common but no significant correlations were found between MRI image changes of LPM, condylar mobility and disc position.</p>

Condyle movement in class II division 1 malocclusion patients after functional appliance treatment / 中华口腔医学杂志

<p><b>OBJECTIVE</b>To record and analyze the characteristics of condyle movement before and after functional treatment in Angle class II division 1 malocclusion (II(1)) patients.</p><p><b>METHODS</b>Twenty Angle II(1) patients were included in the study and 20 Angle I patients without temporomandibular disorders symptoms served as controls. Computer aided diagnosis axiograph (CADIAX) was used to record the condyle movement in Angle II(1) patients and that caused by functional appliance treatment during mouth opening and closing.</p><p><b>RESULTS</b>The tracing were vertically displayed. Value Z [L: 2.21 (1.01) mm, R: 1.12 (1.02) mm] and sagittal condylar inclination [L: 12.89 (9.12) degrees, R: 12.12 (8.89) degrees] were increased significantly in Angle II(1) patients compared with those in control group (P < 0.05). After functional treatment, the condyle movement in Angle II(1) patients was close to normal (P > 0.05).</p><p><b>CONCLUSIONS</b>Typical characteristics of condyle movement were found in Angle II(1) patients and it was stable and repeatable. Functional therapy had a positive effect on temporomandibular joint function in Angle II(1) patients.</p>